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In humans, melatonin is synthesised exclusively from dietary tryptophan, although only a small fraction (12%) is converted via the serotonin pathway

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STEP 4 randomised people whod lost 10.6% on semaglutide to either continue the medication or switch to placebo

9 In people with obesity (body mass index, 31kg/m 2 ), weight loss after 12 months was also greater with dulaglutide (-3kg vs -1.5kg), but gastrointestinal upset (nausea, diarrhoea and vomiting) was more frequent

10.1007/s00125-006-0340-2 117 MatsuiT.NishinoY.TakeuchiM.YamagishiS

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