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Description

Zinman et al., 2018)

Unlike semaglutide, which is a peptide [molecule] that has to be protected from stomach acid degradation, orforglipron is a small molecule that survives the GI tract without special formulation requirements, says John

GLP-1R, GIPR, and GCGR are all present in pancreatic cells

Preclinical and observational data suggested possible benefits, spurring rigorous clinical testing

Understand that averages mask individual variation

Collaborative decision-making between patient and clinician, informed by thorough evaluation and individualized risk assessment, guides optimal management