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Leptin also enhances ECM accumulation by regulating MMPs/TIMPs system, through the activation of MAPKs such as ERK and p38 pathways that lead to the suppression of collagen-degrading enzymes MMP-1 expression while upregulation of its inhibitor TIMP-1 [171, 172]

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tirzepatide and arthritis does help with rheumatoid GLP-1 Drugs Ozempic, Mounjaro, Zepbound: A New Hope for Rheumatoid Arthritis? A Study to Investigate Effectiveness

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