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Its classified as a teratogen , which means it has the potential to cause birth defects or disrupt normal fetal development if taken during pregnancy

That fiscal backdrop helps explain why most public plans have so far limited GLP1 coverage to diabetes, even as evidence for weightloss and cardiometabolic benefits in people with obesity has grown

Indeed, CAPTURE, a multinational, crosssectional study [83] including 9823 adults with T2DM, found that less than 25% of T2DM patients are prescribed a glucose-lowering agent with proven cardiovascular benefit [83]

In the context of liraglutide treatment, Nur77 regulation may help reduce endothelial cell dysfunction in type 2 diabetes and metabolic syndrome [62]

Dose escalation and what to expect at each level GLP-1 therapy always begins with a lower dose and escalates over weeks to months

Many patients had to change up their GLP-1 meds in response to side effects, access problems, insurance coverage or the introduction of new medications