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Whereas both exendin-4 and GLP-1 were found to bind to the same site in the receptor, the crystal structures alone did not adequately explain the reason why exendin-4 has a higher affinity to the isolated NTD of GLP-1R compared to GLP-1

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The results of the risk of bias assessment are summarized in the Table S7

D ietary fiber was shown in a medical review published in The Journal of Nutrition to help reduce body weight when combined with moderate caloric restriction (750 calories per day below baseline)

44 They placed a lactam bridge between Glu i and Lys i +4 at the C-terminal region and showed similar results