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These data suggested that the gut makes a hormone(s) that regulates insulin levels, and they came to be known as incretins which were defined by Creutzfeld as factors that i) are released from gut in response to carbohydrates, ii) stimulate insulin secretion, and iii) act only in the presence of high blood glucose (2)

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ER stress activates the JNK and NF-B pathway followed by UPR activation of the unfolded protein response [141]

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Clin Oral Implants Res (2014) 25(10):11929

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Data shown that dysfunction of autophagy lysosome system can affect the clearance of A peptides and tau proteins, two major features of AD (74)

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Incorporating a balanced diet, regular physical activity, and behavioral changes enhances the benefits of these medications and supports long-term weight loss and maintenance

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