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N Engl J Med 2017;377:1327.ArticlePubMedPMC 4

Even more impressive, over 85% of participants receiving the two highest retatrutide doses achieved complete resolution of steatosis, defined as liver fat content dropping below 5%

But lets first go back briefly to the origin

Conjugates of particular antisense oligonucleotides to a GLP-1 analog enhanced the productive uptake of the oligonucleotide in GLP-1R expressing cells to elicit selective and effective gene silencing in vitro and in vivo with limited off-target accumulation of the oligonucleotide