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The STEP 1 trial of semaglutide (the active ingredient in Ozempic and Wegovy) - published in The New England Journal of Medicine , 2021 - also reported secondary data showing modest lean mass reductions alongside the significant total weight loss the trial is known for

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Loose thigh skin: The thighs also experience significant fat loss, particularly the inner thighs, where the skin is typically thinner and less elastic

Mudaliar S, Henry RR

The standard titration schedule for semaglutide involves starting at a low dosetypically 0.25 mg weekly for the first four weeksand gradually increasing every four weeks until reaching the maintenance dose