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Individual variation in GLP-1 receptor density and sensitivity means some people tolerate these changes quickly while others require longer adjustment periods or dose titration strategies

Some of the common side effects associated with these medications include: feeling sick (nausea) being sick (vomiting) constipation stomach pain weakness or tiredness headache dizziness gas bloating mood changes heartburn or indigestion injection site reactions Some of the less common but severe side effects include: allergic reactions (difficulty breathing and swallowing, wheezing, face or lip swelling, dizziness, and body rash) hip fractures inflamed pancreas (pancreatitis, which may cause severe and persistent stomach pain or vomiting) kidney or bladder stones Most mild side effects will clear up on their own within a few months, once your body has got used to the new medication

Will I need to change my diet or exercise habits

Guidelines recommend ensuring at least four menstrual bleeds per year, using hormonal contraception or cyclic progestogens if needed

Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine , Massachusetts Medical Society, 2021

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