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What makes it so groundbreaking is its dual-action mechanism it mimics both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

However, this effect was not sustained in the long term

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doi: 10.1111/bcp.14855 34 YangWSLeeWJFunahashiTTanakaSMatsuzawaYChaoCLet al

This assumption was confirmed by the STEP 5 trial (long-term weight management), which showed that the efficacy of semaglutide 2.4 mg s.c

For tirzepatide, the starting weekly dose is around 2.5 milligrams and the maximum dose is up to 15 milligrams
