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To accommodate GLP-2 rather than GLP-1, GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices (TMs) 1, 5, 7 and extracellular loop 1 (ECL1)

Disclaimer: These statements have not been evaluated by the FDA

However, weight loss with these drugs also could lower risk for obesity-related cancers

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GLP-1 receptor agonists can reduce thirst signals and increase fluid loss through gastrointestinal changes, making intentional hydration critical during treatment