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Repeated injections in one location can cause lipodystrophy, where the fat tissue under the skin becomes lumpy, hard, or discolored

Jelsing J, Vrang N, Hansen G, Ravn K, Tang-Christensen M, Knudsen LB

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Researchers compared: 10,111 people prescribed a GLP-1 receptor agonist 50,555 matched controls not prescribed one The groups were matched 5:1 by age, sex, baseline exacerbation rate, and prior rescue inhaler prescriptions

The table shows that SGLT2is and aldosterone antagonists provide the most robust and additive reductions in albuminuria and CKD progression, with SGLT2is showing consistent benefit across all albuminuria and eGFR levels [122]