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GLP-1 is primarily produced by special cells in the small intestine known as L-cells

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Data from the FDA Adverse Event Reporting System (a database that reinforces continuous post-marketing surveillance to ensure drug safety) indicate a significant incidence of GI adverse effects in patients using semaglutide

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Neuropsychopharmacology 40, 19691978

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After 72 weeks of treatment, patients treated with semaglutide showed significant reductions in fatty accumulation in the liver as well as liver scarring

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The weight loss it produces follows standard caloric restriction patterns where both fat and muscle are lost

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Lan N, Lu Y, Zhang Y, Pu S, Xi H, Nie X, Liu J, Yuan W (2020) FTO A Common Genetic Basis for Obesity and Cancer

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