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The right choice depends on individual goals, medical history, and tolerance for injection therapy

In mice, the enzyme neprilysin additionally rapidly degrades the metabolites, making GLP-1 difficult to measure in this species [189]

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In rats, liraglutide decreases food intake when directly injected into the ARC, LHA, or PVN while direct administration into the VMH decreases body weight without affecting food intake, but increases the expression of Ucp1 in the brown and inguinal white adipose tissue [666]