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2013;8:e56660

However, there were no significant differences between two groups ( P = 0.69)

Receptor desensitization : Over time, GLP1 receptors may become less responsive to consistent drug exposure, reducing the appetite-suppressing effect

One strategy to address this limitation is to inhibit DPP-4 activity, thereby preventing the inactivation of GLP-1 (Figure 1B)

[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Wu Q, Boyle MP, Palmiter RD

Insurance will not cover it simply because someone is 'overweight' or 'wants to lose weight.' 'Obesity' is a disease concept involving health complications and is clearly distinguished from weight management for cosmetic purposes