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This efficacy rivals or exceeds what phentermine achieves, and because semaglutide's effects compound over time rather than plateau, monotherapy often delivers superior long-term outcomes

Mechanick JI, Farkouh ME, Newman JD, Garvey WT

They usually occur when you start taking semaglutide or increase its dosage during the titration phase

doi: 10.1016/j.jada.2008.04.017 16

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