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For instance, intraperitoneal Ex-4 injection (5 g/kg/day) for 13 days to EAE mice reduced the clinical symptoms, histopathological sequelae (demyelination, astrogliosis, and microglial activation), and mRNA expression of proinflammatory cytokines (IL-1, IL-6, IL-17, and TNF-) (Lee et al., 2018)

K., Kitzman, D