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Given that nausea, vomiting, diarrhea, and constipation are common adverse effects of GLP-1 medicationsparticularly during dose titrationselecting a magnesium supplement that does not exacerbate these symptoms is clinically prudent

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While these medications are generally well-tolerated, GLP-1 safety for non-obese individuals has not been extensively studied

doi: 10.1016/j.bbrc.2019.04.160 [DOI] [PubMed] [Google Scholar] 55.Chang G, Liu J, Qin S, et al

The rationale is that two smaller doses produce a more even medication level throughout the week, avoiding the peak-and-trough pattern that creates intense digestive effects early in the week and diminishing effects late in the week