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GLP-1 in One Sentence If we had to describe GLP-1 in just one sentence, it would be this: GLP-1 is a gut hormone that tells your brain you are full, helps your pancreas handle sugar, and slows digestion so your body is not overwhelmed by food

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Injectable Wegovy produced an average weight loss of around 15 percent in major trials, while tirzepatide, sold as Zepbound for obesity, has produced around 20 percent or more weight loss depending on dose and population

In clinical trials, patients using semaglutide 2.4 mg weekly achieved average weight loss of 1215% of body weight over 68 weeks (approximately 26-33 lbs for a 220-lb person), substantially greater than placebo

The Medication Version GLP-1 medications are synthetic versions of this hormone that work at higher levels than your body typically produces

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