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A small number of trial participants got appendicitis during clinical trials

Our experience working with research teams shows that most post-reconstitution cloudiness develops because the vial was removed from refrigeration multiple times for dosing, allowing the solution to warm above 8C and then recool

All this to say: The level of medical oversight, and the depth of knowledge when it comes to metabolic health, is a wild card

Hyperpigmentation can be difficult to treat with at-home or over the counter remedies, especially for patients with stubborn and extensive situations

doi: 10.1056/NEJMra1610570

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