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Published data (SURMOUNT-4 trial) show most patients regain a meaningful portion of lost weight after discontinuation

The hormone consists of two subunits

Symptoms of high estrogen include water retention, mood changes, decreased libido, and in some cases, breast tissue sensitivity or gynecomastia

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Notable reductions from baseline were observed in alanine aminotransferase (ALT), aspartate aminotransferase (AST), keratin-18 (K-18), procollagen III (Pro-C3), and increases in adiponectin

however, we will not have information on heart risk reduction until ~2027