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Study findings The risk of new-onset DR was slightly higher among GLP-1 RA users (hazard ratio 1.07, a 0.2% absolute increase over two years), but the incidence of NAION was numerically higher but not statistically significant in this group

23, 24, 25 Despite the reliable and potent inhibitory effects of pharmacological activation of GLP-1R on feeding and body weightparadoxically, pharmacological blockade of central GLP-1R, and especially knockout studies of whole-body or neuronal GLP-1R, produce only minor changes in feeding or body weight

Medicine 2024;103:44(e40364)

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