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This dual mechanism is not just semaglutide with an extra ingredient

Prescription medications have reviewed labeling, dosing instructions, adverse-event reporting, manufacturing oversight, and clinician supervision

In a series of clinical trials (SURPASS 1-5) individuals with type 2 diabetes have shown reduction in both HbA1c (1.2 to 2.6%) and body weight (5.411.7 kg) (Nauck and D'Alessio 2022)

Before and after images reflect real results from real patients, although individual results may vary

Results were deemed significant if the confidence interval did not include the null hypothesis (i.e., zero) and if the P value was less than.05

Causes * Severe muscle injury or crush injury * Prolonged seizures * Strenuous exercise * Burns * Electrical injuries * Muscle diseases * Certain drugs (e.g., statins) Clinical Features * Dark brown or tea-colored urine * Muscle pain and tenderness * Muscle weakness * Reduced urine output in severe cases Investigations * Urine dipstick positive for blood but few/no RBCs on microscopy * Markedly elevated creatine kinase (CK) * Elevated serum myoglobin Complications * Acute kidney injury * Electrolyte disturbances (especially hyperkalemia) Management * Aggressive IV fluids * Treat underlying cause * Monitor renal function and electrolytes Hemoglobinuria Definition: Presence of free hemoglobin in urine due to intravascular hemolysis