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J Biol Chem 265, 2025920262 (1990)

Repeatedly applying patches to the same location can cause contact dermatitis, skin sensitization, or localized tissue changes that impair drug absorption

Butyric acid has also been shown to stimulate the proliferation of intestinal mucosal cells, expanding the surface area of the intestinal epithelium and further enhancing calcium absorption, suggesting an inextricable link (Yadav et al., 2010)

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van der Beek CM, Canfora EE, Kip AM, Gorissen SHM, Olde Damink SWM, van Eijk HM, Holst JJ, Blaak EE, Dejong CHC, Lenaerts K