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Higgins JP, et al

Disclaimer: This article is for educational purposes only and does not constitute financial advice

162,163 Retatrutide (LY-3437943), a novel triple agonist developed by Eli Lilly that targets GLP-1R, GIPR and GCGR, has shown potential in preliminary clinical data for providing excellent blood sugar control and significant weight reduction

How to separate hype from evidence

The 12mg group may have had different baseline compositions, or the additional weight loss at 12mg may have included a slightly higher proportion of lean tissue

Thus, we suggest that GIPR and GCGR are unlikely to be responsible for the enhanced effect of the triagonist on insulin secretion
