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FUTURE PERSPECTIVES Long-term outcomes While strong evidence supports the kidney-protective effects of both SGLT2 inhibitors and GLP-1 receptor agonists, the long-term durability of these benefits remains uncertain (Table 2)

Incubation with 1 M L3740 for 48 h has increased GLP-1 secretion and the number of L-cells in human and mouse intestinal organoids through GLP-1R signaling and serotonin signaling

But, even if it is the case that the risk of thyroid cancer turns out to be complete noise, it still wouldnt change the fact that most people would be better off avoiding GLP-1 agonists for the reasons listed here

High creatinine or low eGFR might mean kidney problems

Wright AK, Carr MJ, Kontopantelis E, Leelarathna L, Thabit H, Emsley R, et al

Glucagon-like peptide 1 receptor agonists and cardiovascular outcomes in solid organ transplant recipients with diabetes Mellitus