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Across analyses, a recurring contrast is observed between (i) a reproductive subtypeoften reported as higher LH and SHBG with elevated androgens despite comparatively lower BMI and fasting insulinand (ii) a metabolic subtype, characterized by higher adiposity with higher glucose/insulin measures and lower SHBG (and, in some reports, lower LH) ( n = 11,908), four sub-phenotypes were identified, broadly echoing this metabolicreproductive axis and showing substantial overlap with NIH-based subtyping frameworks ( From a reproductive endocrine perspective, canonical PCOS is characterized by: (i) hyperandrogenism, presenting as hirsutism, acne, and androgenetic alopecia, with elevated total/free testosterone, an increased free androgen index (FAI), and occasionally elevated dehydroepiandrosterone sulfate (DHEAS)

you can find more info in the specific medication guides for Saxenda side effects, Wegovy side effects, or Mounjaro side effects

Notably, nonadherent patients with subsequent blood chemistry measurements may not reflect the treatment's potential benefits accurately, while patients receiving addon treatment could contribute with blood chemistry measurements affected by other treatments

doi: 10.1007/s40259-013-0057-y 127 McCartyDColemanMBolandCL

[DOI] [PubMed] [Google Scholar] 21.Hsu T.M., Noble E.E., Liu C.M., et al

About 69% of semaglutide users lose at least 10% of body weight, compared to approximately 33% of Saxenda users