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Postmenopausal women combining HRT with semaglutide achieved approximately 30 percent more weight loss than those using semaglutide alone

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doi: 10.1016/j.jcjd.2019.05.005 38 ChoiJGWinnANSkandariMRFrancoMIStaabEMAlexanderJet al

Altogether, these chemical modifications manifest in improved bioavailability and a half-life of 12 h [894], supporting once-daily injection in humans

The mechanism of action of GLP-1 agonists involves binding to GLP-1 receptors on pancreatic beta cells, which stimulates glucose-dependent insulin secretion