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The in vivo actions of compound 60 (Figure 7) were also established, including the reduction of plasma DPP-4 activity and the control of rising blood glucose levels

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Loss of CNS GIPR augments weight loss with GLP-1R agonism To examine whether CNS GIPR is required for the additive weight loss effect of combination treatment with mGIPR-Ab and clinically approved GLP-1R agonists, HFD-fed Gipr fl/fl control mice and Gipr Syn/ mice received IP dosing of either vehiclevehicle, dulaglutidevehicle or dulaglutidemGIPR-Ab combination treatments

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Liraglutide did significantly increase weight loss and lower total cholesterol
