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[2] Additionally, findings from SURPASS-1 and SURPASS-2 highlight the importance of gradual dose increases to improve patient adherence and reduce dropouts
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262 It functions not only in peripheral tissues but also directly within the CNS, crossing the blood-brain barrier or being produced centrally to act on the brain
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doi: 10.1016/j.bcp.2021.114578 189 GarabaduDVermaJ
