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doi: 10.1111/dom.14255 Endocrine Society

Clinical trials have documented substantial weight loss with these medicationstypically 15% of body weight with semaglutide 2.4 mg (STEP 1 trial) and approximately 21% with tirzepatide 15 mg (SURMOUNT-1 trial) at 72 weeks

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That is different from never escalating because a marketing page says, microdosing is for everyone. Compounded vials can reduce price, but they raise dosing and quality risks flagged by the FDA

Cotadutide also led to 2.1 kg body weight loss relative to placebo

Analysis of cancer incidence observed in clinical trials of liraglutide