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Hormonal Imbalances: Visceral fat produces hormones like cortisol and affects sex hormones such as testosterone and estrogen

Since retatrutide is still in clinical development , long-term nutritional data is limited compared to semaglutide and tirzepatide

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Digestive Issues : Since both medications can affect digestion, you may experience more pronounced nausea, vomiting, or diarrhea when taking them together

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