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Semaglutide has been around longer (Mounjaro was only approved in 2022), and has a longer track history

This pattern likely reflects differences in baseline fitness: individuals who regularly perform longer workouts are generally more fit and therefore exhibit lower resting heart rate and higher HRV[2]

Some evidence suggests these medications may affect bone turnover, leading to increased bone resorption (breakdown) over time

Women using oral contraceptives should use a non-oral contraceptive method or add a barrier method for 4 weeks after starting Mounjaro and for 4 weeks after each dose escalation

For constipation , start with a stool softener or osmotic laxative for short-term relief, and increase fiber and fluid intake

Optimal results often build over 36 months or more