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For MOTS-c, the endpoints should be more metabolic than membrane-focused: fasting glucose, insulin sensitivity markers, body-weight trend, waist measurement, training tolerance, recovery, liver-enzyme context, lipid markers, and exercise capacity

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Use of GLP-1 drugs was not associated with an increased risk of suicidality compared to either DPP-4 inhibitors or SGLT-2 inhibitors, results show

[PubMed] Mller TD, Finan B, Bloom SR, et al