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They reduce de novo lipogenesis by inhibiting transcription factor sterol regulatory element-binding protein 1c (SREBP-1c), which is a master regulator of fatty acid synthesis ( TABLE 1 Therapeutic actions of GLP-1 receptor agonists in liver disease: summary of experimental and clinical findings
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Epac2 binds to the nucleotide binding domain-1 of the SUR1 subunit of the K ATP channel and this interaction is aborted when levels of cAMP increase (Figure 6) [511]
