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43 In the STEP 1, 3, 4 and 8 trials (the 68week long trials in participants without diabetes), weight loss of 5% (a threshold widely accepted as indicating clinically meaningful response to therapy) 46 was achieved by 86%89% of participants receiving semaglutide 2.4 mg versus 29%48% receiving placebo (Table 2)

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Others have demonstrated that the positive outcomes of obesity surgery (i.e., changes in body weight and improved glucose homeostasis) are sustained in mice in the absence of GLP-1R or Y2-R, or both GLP-1R and Y2-R 66,67

GLP-1 medications for weight loss - what you actually need to know February 19, 2026 GLP-1 medications like Ozempic and Mounjaro have completely changed the weight loss conversation

Novo Nordisk's challenge is that it is now in catch-up mode on efficacy

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