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NICE guidance for the use of GLP-1 receptor agonists in type 2 diabetes (NG28) and for weight management (the current NICE Technology Appraisal for semaglutide 2

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Examples include: Medical contraindications to GLP-1 therapy Lack of clinical supervision No structured plan for muscle preservation Hormonal status not yet evaluated Reducing the dose does not remove contraindications or eliminate underlying medical risks

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