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tirzepatide, early research suggests that retatrutide may lead to the greatest average weight loss

Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies

The safety profile of dual agonists is similar to pure GLP-1 agonists, with the main difference being slightly higher rates of GI side effects

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N Eng J Med 329(20):14561462
Recently, several studies have shown that GLP-1RAs may also have beneficial effects in the management of NAFLD [12,13]