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Efinopegdutide is another GLP-1R and GCGR dual agonist currently under clinical investigation, which is being explored in studies for patients with obesity, type 2 diabetes (T2D), and metabolically associated fatty liver disease/multiple acyl-CoA dehydrogenase deficiency syndrome (MASLD/MASH)

Furthermore, GLP-1 analogs may restore insulin secretion by activating the GLP-1 receptor (GLP-1R)-Gs signals because GLP-1 analogs overcome SSTR5-Gi signals in pancreatic -cells under the condition of suppressed insulin production and spare suppressed incretin secretion from intestinal L-cells 27

[1] Importantly, tirzepatide may reduce oral contraceptive absorption

The pattern of central nervous system expression of MCH and MCH1R suggests that this peptide-receptor system is involved in a host of physiological functions within the brain

It can also suggest bone disorders, such as Pagets disease, bone fractures, or conditions causing increased bone turnover like hyperparathyroidism

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