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Description
It can be administered at any time within the 60 minutes before the two main meals of the day, more than six hours apart

If malnutrition continues despite appropriate dosing, a consultation with a dietitian is suggested to evaluate and modify enzyme therapy and total dietary energy

Multiple randomized controlled trials demonstrate that GLP-1 receptor agonists produce 15-22% average body weight loss over 68 weeks, with cardiovascular benefits including reduced blood pressure and improved metabolic markers
Survodutide (BI 456906) is a GLP-1/glucagon co-agonist which has progressed to phase 3 clinical trials as treatment for obesity (SYNCHRONIZE programme)

A worst-case scenario of the relative infant dose (RID) was calculated using the LLOQ as the drug concentration in milk when considering semaglutides bioavailability and long-acting dose profile

Axelsen M, Sidhu S
