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And that's good news for your health

For others, comparable progress can be achieved by correcting metabolic drivers through targeted nutrition, resistance training, sleep optimization, stress regulation, and individualized assessment

However, recent Phase III data for the trifunctional GLP-1/GIP/Glucagon receptor agonist retatrutide show average weight loss of around 28.7%, significantly exceeding results from GLP-1 monotherapy

The study, which was published in American Journal of Ophthalmology , analyzed data over about a three-year period from 71 US healthcare organizations of 41,850 patients who initiated tirzepatide and 147,828 patients who initiated selective GLP-1 drugs

RELATED: Worried about 'Ozempic butt?' New drug could stop muscle loss tied to weight loss injections Obesity declines, diabetes levels stabilize Dig deeper: After peaking at 39.9% in 2022, the national adult obesity rate has fallen to 36.4% in 2026, mirroring ring GLP-1 usage

By boosting the expression of osteoclastogenic indicators following GLP-1R knockdown, the authors established that GLP-1R might be relevant for osteoclastogenesis and validated the presence of GLP-1R on BMMs and RAW264.7 cells
