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The STEP 1 trial (Wilding et al., 2021), one of the largest studies on semaglutide, found that 39% of the weight lost over 68 weeks was lean mass

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Although blood pressure lowering is an established mechanism for reducing MACE, the magnitude seen with GLP-1RAs is likely insufficient to explain the full extent of CV benefit (66)

The risk is highest in the first six months of treatment and includes about twice the likelihood of needing gallbladder removal surgery

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