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Importantly, GLP-1 receptor agonism has been demonstrated in several fibrotic models to lead to inhibition of TGF- signalling

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Patch clamp electrophysiology Membrane currents were recorded in the whole-cell configuration under conditions of voltage clamp in which cells were bathed in SES 33,34

An intriguing and likely possibility is the potential function of GIP to enhance the actions of GLP-1

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Compare to the control group, higher expression of p65, IL-6, TNF-, and ratio of p-IB/IB were noted in TG group indicating the activation of NF-B pathway and associated inflammatory response may relate to ER stress