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Beyond, many of the observed changes occurred in patients with BD can be considered as signs of premature aging (telomere length, oxidative stress, inflammation, disruptions on biological clocks, epigenetic aging and mitochondrial dysfunction), as prior works hypothesize that accelerated aging process is potentially implicated in the development and course of BD [52]

10.1172/jci168553 J

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Bupleurum falcatum has been utilized in Chinese medicine form more than 2000 years as a liver tonic

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Rats were acclimated to the experimental conditions by daily handling during 7 days