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Once appetite suppression quiets so-called food noise, expectations around fullness and portioning shift, particularly for long-term users

This limitation highlights the inherent difficulties of performing a meta-analysis that relies exclusively on retrospective cohorts

While take-up is uncertain, interest in the program among potentially eligible Medicare beneficiaries is likely to be strong

This creates a vicious cycle: stress raises cortisol, cortisol drives weight gain and appetite, and impaired GLP-1 signaling perpetuates the problem