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The GWAS was performed including covariates as described in equation 1 above, with the addition of five genetic principal components to account for fine-scale genetic ancestry, and indicator variables to account for variation in the genotyping platform

Glucagon is liberated from pancreatic cells by PC2, wherea GLP-1 and GLP-2 are liberated from the intestinal L cells by PC1/3

Randomized, double-blind, phase 3 trial of triple therapy with dapagliflozin add-on to saxagliptin plus metformin in type 2 diabetes

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Tesamorelin holds no UK marketing authorisation and would require importation as an unlicensed medicine on a named-patient basis, with full clinical and legal responsibility resting with the prescribing clinician

Highlights are mine The side effects for HRS9531 are essentially in line with orforglipron and in some respects, especially vomiting and diarrhea, are worse