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5.6 Necrotizing Fasciitis of the Perineum (Fourniers Gangrene) Reports of necrotizing fasciitis of the perineum (Fourniers Gangrene), a rare but serious and life-threatening necrotizing infection requiring urgent surgical intervention, have been identified in postmarketing surveillance in patients with diabetes mellitus receiving SGLT2 inhibitors, including dapagliflozin

As one of the fastest growing classes of medications, GLP-1 weight-loss drugs were originally brought on the market to treat diabetes

Main measures The incidence of intestinal obstruction was compared between GLP-1RAs and each of six other classes of non-GLP-1RA anti-diabetic medications