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Their analysis shows that excluding GLP-1 assets from the model would reduce the average IRR from 5.9% to just 3.8%, highlighting their outsized impact on industry performance

These are not trivial findings for someone whose disease activity correlates with systemic inflammation levels

Furthermore, the distribution of contributing physicians in the study, approximately 50% primary care practitioners and 50% specialists, presents a notable point of interest due to the potential disparities in the care each group may offer and merits further investigation

10.14309/01.ajg.0000595080.14595.de 6 AyoubW

As the new calendar year unfolds, many employers are reassessing coverage options, balancing the potential benefits of improved employee health and satisfaction against their concern for budget impact due to the high cost of GLP-1s

In clinical trials such as SURPASS and SURPASS-2, tirzepatide demonstrated comparable or superior efficacy to semaglutide in improving HbA1c and reducing BMI, with weight reductions of 5.4 to 10.5 kg and up to 2.34% HbA1c reduction at 40 weeks.16,17 Tirzepatide is administered as a weekly injection beginning at 2.5 mg weekly and increasing to 5 mg after four weeks
