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GLP-1 medications reduce appetite and slow gastric emptying, but they work with food choices and activity, not instead of them

However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists

Starting at week 5, if well-tolerated, your doctor may recommend doubling your dose to 0.5 mg, which you should maintain for another 4 weeks

Because obesity increases the risk of diabetes, heart disease, certain cancers and many other serious chronic conditions, identifying the right therapy sooner could improve long-term health outcomes

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