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Semaglutide and Direct GLP-1 Regulation of Appetite in the Brain Widely distributed in the brain CNS, GLP-1Rs display a crucial role in the regulation of hunger, satiety and feeding behavior to reduce energy intake [113,114]
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Ferdinand KC, White WB, Calhoun DA, Lonn EM, Sager PT, Brunelle R, Jiang HH, Threlkeld RJ, Robertson KE, Geiger MJ
These trade-offs will likely inform how clinicians and the FDA approach the final approved dose range
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